course

CATEGORY

Department of Digestive Surgery

Department of Digestive Surgery

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Staff

This department consists of 3 sections: upper gastrointestinal section, lower gastrointestinal section, and hepatobiliary and pancreatic surgery section

Research projects

  • Analysis of human small intestinal submucosa and preparation of grafts by decellularization

    We analysis human small intestinal submucosa (SIS) removed during surgery and decellularize them on a petri dish. We test various decellularization processes for human SIS graft in which we keep the native structure of the extracellular matrix and optimal conditions of growth/proliferation factors.

  • Development of a new therapeutic strategy for unresectable poorly differentiated gastric cancer with the aim of suppressing c-MET signaling pathway

    We are focusing on c-MET inhibitors in order to develop a pharmacotherapy regimen aimed at conversion therapy with excellent tumor-reducing effect that leads to R0 resection in patients with poorly differentiated adenocarcinoma of the stomach. This study is carried out to evaluate the combined effects of c-MET inhibitor and anticancer agents in vitro and in vivo using poorly differentiated gastric adenocarcinoma cell lines. Furthermore, we are also studying the combined effect (synergistic effect) with STAT3 and c-MET inhibitors under the same conditions.

    We expect to develop a new therapeutic strategy for unresectable gastric cancer patients with poorly differentiated adenocarcinoma.

  • Research on relationship between Brachyury expression and prognosis in gastrointestinal stromal tumor (GIST)

    We are analyzing Brachyury expression by immunohistochemistry in a cohort of GIST patients with a confirmed diagnosis, and are examining its relationship with prognosis. If the Branchyury immunostaining score can be a predictor of prognosis, GIST patients will be able to have a new treatment option.