Staff
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ProfessorTomoyuki MukaiTomoyuki Mukai
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Assistant ProfessorMasanori IsekiMasanori Iseki
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InstructorYuma SakamotoYuma Sakamoto
Research Interests
Our department is dedicated to the following research areas. (1) Pathophysiological analysis of autoinflammatory diseases. We have identified the pathogenic mechanisms of TNF receptor-associated periodic syndrome (TRAPS) and autoinflammatory bone disorder cherubism. (2) Inflammatory linkages between psoriasis and metabolic syndromes. We have shown that obesity and hyperlipidemia synergistically exacerbate psoriatic skin inflammation. (3) Cytokine component EBI3 in various immune/inflammatory diseases. We are analyzing the role of EBI3 in pathogenesis using mutant mice.
Recent publications
- Ikeda K, Mukai T, et al. Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation. Int J Mol Sci. 2022;23(8):4312. doi: 10.3390/ijms23084312.
- Mukai T, et al. Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model. Oral Dis. 2021:10.1111/odi.14073. doi: 10.1111/odi.14073.
- Hiramatsu-Asano S, Mukai T, et al. IL-17A promotes vascular calcification in an ex vivo murine aorta culture. Biochem Biophys Res Commun. 2022;604:83-87. doi: 10.1016/j.bbrc.2022.03.051.
- Kawahara K, Mukai T, et al. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus. Int J Mol Sci. 2021;22(8):4169. doi: 10.3390/ijms22084169.