Staff
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ProfessorHajime NagasuHajime Nagasu
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Assistant ProfessorSeiji ItanoSeiji Itano
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Assistant ProfessorKengo KidokoroKengo Kidokoro
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Assistant ProfessorYoshihisa WadaYoshihisa Wada
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InstructorEimei OkamotoEimei Okamoto
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InstructorNatsumi InoueNatsumi Inoue
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InstructorManabu KadoManabu Kado
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InstructorAkira HiranoAkira Hirano
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InstructorRie TatsugawaRie Tatsugawa
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InstructorSaki NakamuraSaki Nakamura
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InstructorNobuhiro NakamuraNobuhiro Nakamura
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InstructorYasuhiro MurataYasuhiro Murata
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InstructorEriko KajimotoEriko Kajimoto
Laboratory Overview / Research Introduction
Our laboratory conducts a wide range of basic and clinical research aimed at understanding disease mechanisms and developing novel therapies for kidney disease and hypertension.
Chronic Kidney Disease (CKD) progresses to end-stage renal disease and is likewise established as a major risk factor for cardiovascular diseases, such as stroke and myocardial infarction. Preventing the onset and progression of CKD is crucial—both to reduce the number of patients requiring dialysis to prevent cardiovascular events. Furthermore, hypertension is not only one of the most critical risk factors for cardiovascular disease but also a potent exacerbating factor that accelerates CKD progression.
To suppress cardiovascular and renal diseases, our laboratory investigates CKD, hypertension, associated organ complications, and the systemic vasculature. In particular, we utilize intravital imaging technology to evaluate in vivo hemodynamics and biological activities, actively pursuing reverse translational research.
Our Main Research
- Elucidation of the regulatory mechanism of glomerular filtration rate via the Keap1-Nrf2 pathway
- Elucidation of the mechanisms underlying the renoprotective effects of non-steroidal mineralocorticoid receptor (MR) antagonists against diabetic kidney disease
- Elucidation of the mechanisms underlying the renoprotective effects of SGLT2 inhibitors against diabetic kidney disease and non-diabetic chronic kidney disease
- Elucidation of the link between the inflammasome and mitochondrial stress
- Elucidation of the relationship between DNA damage and renal aging
- Elucidation of the mechanisms driving kidney disease progression mediated by the muscle-kidney-mitochondria axis
- Elucidation of the mechanisms by which the eNOS-NO pathway and related signaling pathways affect the progression and exacerbation of kidney disease
- Elucidation of the mechanism regulating TRPC activation via sGC activation in glomerular endothelial-epithelial cell crosstalk