Our Research

Lysosomes are acidic organelles responsible for the intracellular degradation system. Various inherited lysosomal diseases (lysosomal storage disease) are caused by genetic abnormalities of more than 50 kinds of lysosomal enzymes, but pathophysiological mechanisms caused by the dysfunction of lysosomes at the cellular level, organ level, and whole body, are not fully elucidated. Also, recently, new diseases have been found one after another by exome analysis. We are engaged in research to clarify the molecular mechanism of these genetic disorders and link them to therapeutic methods.

Our laboratory was newly established in 2019. Graduate students and post-doctoral fellows, as well as collaborations are welcome.

  • Lysosome
  • Autophagy
  • Lysosomal storage diseases (LSD)
  • Mucolipidoses (ML II, ML III)
  • Mucopolysaccharidosis plus syndrome (MPSPS)
  • GNPTAB, GNPTG, VPS33A genes

Contact Address

Kawasaki Medical School, Department of Molecular and Genetic Medicine
Professor Takanobu OTOMO, MD, PhD

Address: 577, Matsushima, Kurashiki-city, Okayama 701-0192, JAPAN
Tel: +81 (0)86 462 1111 / Fax: +81 (0)86 462 1199
E-mail: mgm-lyso [at] med.kawasaki-m.ac.jp (Please change [at] to @)