Research Papers

2019

Laboratory Hematology Branch

Sakakibara K, Tsujioka T, Kida JI, Kurozumi N, Nakahara T, Suemori SI, Kitanaka A, Arao Y, Tohyama K: Binimetinib, a novel MEK1/2 inhibitor, exerts anti-leukemic effects under inactive status of PI3Kinase/Akt pathway. Int J Hematol 110: 213-227, 2019. (doi: 10.1007/s12185-019-02667-1)

Kawabata H, Usuki K, Shindo-Ueda M, Kanda J, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Miyazaki Y, Kurokawa M, Arai S, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes: Serum ferritin levels at diagnosis predict prognosis in patients with low blast count myelodysplastic syndromes. Int J Hematol 110: 533-542, 2019. (doi: 10.1007/s12185-019-02710-1)

Murakami Y, Kimura Y, Kawahara A, Mitsuyasu S, Miyake H, Tohyama K, Endo Y, Yoshida N, Imamura Y, Watari K, Ono M, Okamura T, Kuwano M: The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes. Oncotarget 10(23):2270-2281, 2019. (doi: 10.18632/oncotarget.26784)

Shide K, Kameda T, Kamiunten A, Oji A, Ozono Y, Sekine M, Honda A, Kitanaka A, Akizuki K, Tahira Y, Nakamura K, Hidaka T, Kubuki Y, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hasuike S, Yamamoto S, Nagata K, Ikawa M, Shimoda K: Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis. Blood Cancer J 29;9(4):42. 2019 Mar. (doi: 10.1038/s41408-019-0202-z. PMID: 30926777)

Endoscopy and Ultrasonography Branch

Manabe N, Kamada T, Kusunoki H, Hata J, Haruma K: Usefulness of ultrasonographic evaluation of stool and/or gas distribution for the treatment strategy of chronic constipation. Journal of gastroenterology and hepatology open. 3(4):310-315. 2019.

2018

Laboratory Hematology Branch

Morita H, Matsuoka A, Kida JI, Tabata H, Tohyama K, Tohyama Y: KIF20A, highly expressed in immature hematopoietic cells, supports the growth of HL60 cell line. Int J Hematol 108: 607-614, 2018. (doi: 10.1007/s12185-018-2527-y)

Matsuda A, Kawabata H, Tohyama K, Maeda T, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Usuki K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Ohta A, Miyazaki Y, Nakao S, Ozawa K, Arai S, Kurokawa M, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes: Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study.Leuk Res 74: 137-143, 2018. (doi:10.1016/j.leukres.2018.06.003)

Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, Du J, Wang H, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua WK, Zhang B, Feng L, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kortylewski M, Pichiorri F, Kuo YH, Carlesso N, Marcucci G, Jin H, Li L: SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. Cell Stem Cell 23: 355-369, 2018.

Kida J, Tsujioka T, Suemori S, Okamoto S, Sakakibara K, Takahata T, Yamauchi T, Kitanaka A, Tohyama Y, Tohyama K: An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS.Leukemia, 32: 1846-1850, 2018.

Nakahara T, Suemori S, Tsujioka T, Kataoka M, Kataoka H, Shibakura M, Tohyama K : Utility of a Fluorescence Microscopy Imaging System for Analyzing the DNA Ploidy of Pathological Megakaryocytes Including 5q- Syndrome.Acta Medica Okayama, 72: 249-256, 2018.

Tohyama K: Present status and perspective of laboratory hematology in Japan: On the standardization of blood cell morphology including myelodysplasia: On behalf of the Japanese Society for Laboratory Hematology. Int J Lab Hematol,40(Suppl 1): 120-125, 2018.

Maruoka T, Kitanaka A, Kubota Y, Yamaoka G, Kameda T, Imataki O, Dobashi H, Bandoh S, Kadowaki N, Tanaka T: Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents. Int J Oncol, 52(5):1738-1748. 2018 May. (doi: 10.3892/ijo.2018.4314. Epub 2018 Mar 13. PMID: 29568932)

Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S: Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. Blood, 11;131(2):215-225. 2018 Jan. (doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30. PMID: 29084771)

Endoscopy and Ultrasonography Branch

Manabe N, Kamada T, Hata J, Haruma K: New ultrasonographic evaluation of stool and/or gas distribution for treatment of chronic constipation. International journal of colorectal disease. 33(3):345-348. 2018.

Manabe N, Haruma K, Kusunoki H, Kamada T, Hata: Differences in salivary secretory function between patients with erosive esophagitis and those with nonerosive reflux disease. Journal of gastroenterology and hepatology. 33(4):807-813. 2018.

Fujita M, Murao T, Osawa M, Hirai S, Fukushima S, Yo S, Nakato R, Ishii M, Matsumoto H, Tamaki T, Sakakibara T, Shiotani A: Colonic endoscopic mucosal resection in patients taking anticoagulants: Is heparin bridging therapy necessary? Journal of digestive diseases. 19(5):288-294. 2018.

Manabe N, Haruma K, Nakato R, Kusunoki H, Kamada T, Hata J: New ultrasonographic screening method for oropharyngeal dysphagia: tissue Doppler imaging. Am J Physiol Gastrointest Liver Physiol. 314(1):G32-G38. 2018.

2017

Laboratory Hematology Branch

Oben　KZ, Alhakeem SS , McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills Jr HF, St. Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S : Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by withaferin-A. Oncotarget 8: 77436-77452, 2017.

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes: A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Am J Hematol 92: 1324-1332, 2017.

Kawabata H, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Zaike Y, Usuki K, Chiba S, Ishikawa T, Arima N, Nogawa M, Ohta A, Miyazaki Y, Mitani K, Ozawa K, Arai S, Kurokawa M, Takaori-Kondo A : Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes: Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry. Int J Hematol 106: 375-384, 2017.

Li L, Sheng Y, Li W, Hu C, Mittal N, Tohyama K, Seba A, Zhao YY, Ozer H, Zhu T, Qian Z : Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes:β-catenin is a candidate therapeutic target for myeloid neoplasms with del(5q). Cancer Res 77: 4116-4126, 2017.

Sekine M, Kubuki Y, Kameda T, Takeuchi M, Toyama T, Kawano N, Maeda K, Sato S, Ishizaki J, Kawano H, Kamiunten A, Akizuki K, Tahira Y, Shimoda H, Shide K, Hidaka T, Kitanaka A, Yamashita K, Matsuoka H, Shimoda K : Effects of mogamulizumab in adult T-cell leukemia/lymphoma in clinical practice. European journal of haematology 98(5): 501-507, 2017.

Kubuki Y, Yamaji T, Hidaka T, Kameda T, Shide K, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Kitanaka A, Shimoda K: TET2 mutation in diffuse large B-cell lymphoma. Journal of clinical and experimental hematopathology 56(3): 145-149, 2017.

Shimosaki S, Nakahata S, Ichikawa T, Kitanaka A, Kameda T, Hidaka T, Kubuki Y, Kurosawa G, Zhang L, Sudo Y, Shimoda K, Morishita K : Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. Biochemical and biophysical research communications 485(1): 144-151, 2017.

Kubuki Y, Shide K, Kameda T, Yamaji T, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hashimoto K, Yamamoto S, Hasuike S, Hidaka T, Nagata K, Kitanaka A, Shimoda K : Differences in Hematological and Clinical Features Between Essential Thrombocythemia Cases With JAK2- or CALR-Mutations.Annals of laboratory medicine (2): 159-161, 2017.

Kubuki Y, Yamaji T, Hidaka T, Kameda T, Shide K, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Kitanaka A, Shimoda K: TET2 mutation in diffuse large B-cell lymphoma. J Clin Exp Hematop 56(3):145-149. 2017. (doi: 10.3960/jslrt.56.145. PMID: 28331128)

Shimosaki S, Nakahata S, Ichikawa T, Kitanaka A, Kameda T, Hidaka T, Kubuki Y, Kurosawa G, Zhang L, Sudo Y, Shimoda K, Morishita K: Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. Biochem Biophys Res Commun 25;485(1):144-151. 2017 Mar. (doi: 10.1016/j.bbrc.2017.02.039. Epub 2017 Feb 8. PMID: 28189691)

Sekine M, Kubuki Y, Kameda T, Takeuchi M, Toyama T, Kawano N, Maeda K, Sato S, Ishizaki J, Kawano H, Kamiunten A, Akizuki K, Tahira Y, Shimoda H, Shide K, Hidaka T, Kitanaka A, Yamashita K, Matsuoka H, Shimoda K: Effects of mogamulizumab in adult T-cell leukemia/lymphoma in clinical practice. Eur J Haematol 98(5):501-507. 2017 May. (doi: 10.1111/ejh.12863. Epub 2017 Mar 10. PMID: 28152225)

Kubuki Y, Shide K, Kameda T, Yamaji T, Sekine M, Kamiunten A, Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hashimoto K, Yamamoto S, Hasuike S, Hidaka T, Nagata K, Kitanaka A, Shimoda K: Differences in Hematological and Clinical Features Between Essential Thrombocythemia Cases With JAK2- or CALR-Mutations. Ann Lab Med 37(2):159-161. 2017 Mar. (doi: 10.3343/alm.2017.37.2.159. PMID: 28029004)

Shide K, Kameda T, Yamaji T, Sekine M, Inada N, Kamiunten A, Akizuki K, Nakamura K, Hidaka T, Kubuki Y, Shimoda H, Kitanaka A, Honda A, Sawaguchi A, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hasuike S, Yamamoto S, Nagata K, Shimoda K: Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib. Leukemia 31(5):1136-1144. 2017 May. (doi: 10.1038/leu.2016.308. Epub 2016 Nov 3. PMID: 27807369)

Endoscopy and Ultrasonography Branch

Fujita M, Manabe N, Murao T, Osawa M, Hirai S, Fukushima S, Shogen Y, Nakato R, Ishii M, Matsumoto H, Hata J, Shiotani A: Differences in the clinical course of 516 Japanese patients with upper gastrointestinal bleeding between weekday and weekend admissions. Scandinavian journal of gastroenterology. 52(12):1365-1370. 2017.

Nakato R, Manabe N, Shimizu S, Hanayama K, Shiotani A, Hata J, Haruma K: Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study. Digestion. 95(3):210-220. 2017.

Sakaguchi M, Manabe N, Ueki N, Miwa J, Inaba T, Yoshida N, Sakurai K, Nakagawa M, Yamada H, Saito M, Nakada K, Iwakiri K, Joh T, Haruma K: Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study. World journal of gastroenterology. 23(2):318-327. 2017.

Nakato R, Manabe N, Kamada T, Matsumoto H, Shiotani A, Hata J, Haruma K: Age-Related Differences in Clinical Characteristics and Esophageal Motility in Patients with Dysphagia. Dysphagia. 32(3):374-382. 2017.

2016

Laboratory Hematology Branch

Okamoto S, Tsujioka T, Suemori S, Kida J, Kondo T, Tohyama Y, Tohyama K: Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression. Cancer Sci 107: 1302-1314, 2016.

Kondo T, Tasaka T, Tomioka N, Sano F, Tokunaga H, Suemori S, Tsujioka T, Matsuhashi Y, Nakanishi H, Wada H, Tohyama K, Sugihara T: Low neutrophil alkaline phosphatase score is a new aspect of calreticulin-mutated myeloproliferative neoplasms. Springerplus 5: e1146, 2016.

Kobayashi S, Ueda Y, Nannya Y, Shibayama H, Tamura H, Ogata K, Akatsuka Y, Usuki K, Ito Y, Okada M, Suzuki T, Hata T, Matsuda A, Tohyama K, Kakumoto K, Koga D, Mitani K, Naoe T, Sugiyama H, Takaku F: Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes. Cancer Biomark 17: 21-32, 2016.

Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S: Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers. Nature 534(7607): 402-406, 2016.

Kitanaka A, Takenaka K, Shide K, Miyamoto T, Kondo T, Ozawa K, Kurokawa M, Akashi K, Shimoda K: Splenic irradiation provides transient palliation for symptomatic splenomegaly associated with primary myelofibrosis: a report on 14 patients. International journal of hematology 103(4): 423-428, 2016.

Endoscopy and Ultrasonography Branch

Tsukamoto M, Manabe N, Kamada T, Hirai T, Hata J, Haruma K, Inoue K: Number of Gastrointestinal Symptoms is a Useful Means of Identifying Patients with Cancer for Dysphagia. Dysphagia. 31(4):547-54. 2016.

Tanaka T, Fujita M, Bottino R, Piganelli JD, McGrath K, Li J, Lee W, Iwase H, Wijkstrom M, Bertera S, Long C, Landsittel D, Haruma K, Cooper DK, Hara H: Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs. Islets. 8(1):1-12. 2016.

2015

Laboratory Hematology Branch

Tsujioka T, Yokoi A, Itano Y, Takahashi K, Ouchida M, Okamoto S, Kondo T, Suemori S, Tohyama Y, Tohyama K: Five-aza-2’-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells. Sci Rep 5: e16709, 2015.

Matsumoto H, Okumura H, Murakami H, Kubota H, Higashida M, Tsuruta A, Tohyama K, Hirai T: Fluctuation in plasma 5-fluorouracil concentration during continuous 5-fluorouracil infusion for colorectal cancer.Anticancer Res 35: 6193-6199, 2015.

Suemori S, Wada H, Nakanishi H, Tsujioka T, Sugihara T, Tohyama K: Analysis of hereditary elliptocytosis with decreased binding of eosin-5-maleimide to red blood cells. BioMed Res Int (Special Issue on “Phylogeny and Ontogeny of Erythropoiesis”), Vol 2015, Article ID 451861 (e1-6), 2015.

Hyoda T, Tsujioka T, Nakahara T, Suemori S, Okamoto S, Kataoka M, Tohyama K: Rigosertib induces cell death of an MDS-derived cell line by DNA damage-induced G2/M arrest. Cancer Sci 106: 287-293, 2015.

Endoscopy and Ultrasonography Branch

Manabe N, Haruma K, Nakajima A, Yamada M, Maruyama Y, Gushimiyagi M, Yamamoto T: Characteristics of Colonic Diverticulitis and Factors Associated With Complications: A Japanese Multicenter, Retrospective, Cross-Sectional Study. Diseases of the colon and rectum. 58(12):1174-81. 2015.

Fujita M, Manabe N, Honda K, Murao T, Osawa M, Kawai R, Akiyama T, Shiotani A, Haruma K, Hata J: Usefulness of Ultrasonography for Diagnosis of Small Bowel Tumors: A Comparison Between Ultrasonography and Endoscopic Modalities. Medicine(Baltimore). 94(40):e1464. 2015.

Fujita M, Shiotani A, Murao T, Ishii M, Yamanaka Y, Nakato R, Matsumoto H, Tarumi K, Manabe N, Kamada T, Hata J, Haruma K: Safety of gastrointestinal endoscopic biopsy in patients taking antithrombotics. Digestive endoscopy. 27(1):25-9. 2015.

2014

Laboratory Hematology Branch

Hayashi K, Tasaka T, Hirose T, Furukawa S, Kohguchi K, Matsuhashi Y, Wada H, Tohyama K, Sugihara T: Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome. Intern Med 53: 2635-2638, 2014.

Hu X-M, Yuan B, Tanaka S, Song M-M, Onda K, Tohyama K, Zhou A-X, Toyoda H, Hirano T: Arsenic disulfide-triggered apoptosis and erythroid differentiation in myelodysplastic syndrome and acute myeloid leukemia cell lines. Hematology, 19: 352-360, 2014.

Rhyasen GW, Wunderlich M, Tohyama K, Garcia-Manero G, Mulloy JC, Starczynowski DT: An MDS xenograft model utilizing a patient-derived cell line. Leukemia 28: 1142-1145, 2014.

Kawakami T, He J, Morita H, Yokoyama K, Kaji H, Tanaka C, Suemori S, Tohyama K, Tohyama Y: Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells. PLoS One 9: e84704, 2014.

Endoscopy and Ultrasonography Branch

Manabe N, Tsutsui H, Kusunoki H, Hata J, Haruma K: Pathophysiology and treatment of patients with globus sensation–from the viewpoint of esophageal motility dysfunction. Journal of smooth muscle research. 50:66-77. 2014.

2013

Laboratory Hematology Branch

Tsujioka T, Yokoi A, Uesugi A, Kishimoto M, Tochigi A, Suemori S, Tohyama Y, Tohyama K: Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines. Exp Hematol 41: 189-197, 2013.

Ueda Y, Mizutani C, Nannya Y, Kurokawa M, Kobayashi S, Takeuchi J, Tamura H, Ogata K, Dan K, Shibayama H, Kanakura Y, Niimi K, Sasaki K, Watanabe M, Emi N, Teramura M, Motoji T, Kida M, Usuki K, Takada S, Sakura T, Ito Y, Ohyashiki K, Ogawa H, Suzuki T, Ozawa K, Imai K, Kasai M, Hata T, Miyazaki Y, Morita Y, Kanamaru A, Matsuda A, Tohyama K, Koga D, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F: Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes. Leuk Lymphoma 54: 1450-1458, 2013.

Nagase S, Kohguchi K, Tohyama K, Watanabe M, Iwatani Y: Interference by pralidoxime (PAM) salts in clinical laboratory tests.
Clin Chim Acta 416: 72-79, 2013.

Endoscopy and Ultrasonography Branch

Furukawa N, Manabe N, Kase Y, Hattori T, Imamura H, Kusunoki H, Haruma K: Intragastric infusion of rikkunshito (kampo) induces proximal stomach relaxation in conscious dogs. Autonomic neuroscience. 179(1-2):14-22. 2013.

Fujita M, McGrath KM, Bottino R, Dons EM, Long C, Kumar G, Ekser B, Echeverri GJ, Hata J, Haruma K, Cooper DK, Hara H: Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs. Cell transplantation. 22(12):2335-44. 2013.Fujita M, Mehra R, Lee SE, Roh DS, Long C, Funderburgh JL, Ayares DL, Cooper DK, Hara H: Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells. Ophthalmic research. 49(3):127-38. 2013.

2012

Laboratory Hematology Branch

Imashuku S, Kudo N, Kubo K, Saigo K, Okuno N, Tohyama K: Rituximab for managing acquired hemophilia A in a case of chronic neutrophilic leukemia with the JAK2 kinase V617F mutation. J Blood Med 3: 157-61, 2012.

Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F: Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: A multicenter validation study. Leuk Res 36: 1229-1236, 2012.

Oki Y, Kondo Y, Yamamoto K, Ogura M, Kasai M, Kobayashi Y, Watanabe T, Uike N, Ohyashiki K, Okamoto S, Ohnishi K, Tomita A, Miyazaki Y, Tohyama K, Mukai HY, Hotta T, Tomonaga M: Phase I/II study of decitabine in patients with myelodysplastic syndrome: A multi-center study in Japan. Cancer Sci 103: 1839-1847, 2012.

Imashuku S, Kudo N, Kubo K, Takahashi N, Tohyama K: Persistent thrombocytosis in elderly patients with rare hyposplenias that mimic essential thrombocythemia. Int J Hematol 95: 702-705, 2012.

Yoshida A, Zokumasu K, Wano Y, Yamauchi T, Imamura S, Takagi K, Kishi S, Urasaki Y, Tohyama K, Ueda T: Marked upregulation of Survivin and Aurora-B kinase are associated with disease progression in the myelodysplastic syndromes. Haematologica 97: 1372-1379, 2012.

Tohyama K : Editorial (as the Executive Guest Editor): New treatment strategy of the myelodysplastic syndromes. Curr Pharm Design 18: 3147-3148, 2012.

Tohyama K: Utility of DNA methyltransferase inhibitors for the treatment of myelodysplastic syndromes. Curr Pharm Design 18: 3190-3197, 2012.

Tsujioka T, Matsuoka A, Tohyama Y, Tohyama K: Approach to new therapeutics: Investigation by the use of MDS-derived cell lines. Curr Pharm Design 18: 3204-3214, 2012.

Matsuda A, Taniwaki M, Jinnai I, Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Tohyama K, Takatoku M, Ozawa K: Morphologic analysis in myelodysplastic syndromes with del(5q) treated with lenalidomide. A Japanese multiinstitutional study. Leuk Res 36: 575-580, 2012.

Tanaka C, Kaji H, He J, Hazama R, Yokoyama K, Kinoshita E, Tsujioka T, Tohyama K, Yamamura H, Nishio H, Tohyama Y: Rab27b regulates c-kit expression by controling the secretion of stem cell factor. Biochem Biophys Res Comm 419: 368-373, 2012.

Endoscopy and Ultrasonography Branch

Tsutsui H, Manabe N, Uno M, Imamura H, Kamada T, Kusunoki H, Shiotani A, Hata J, Harada T, Haruma K: Esophageal motor dysfunction plays a key role in GERD with globus sensation–analysis of factors promoting resistance to PPI therapy. Scandinavian journal of gastroenterology. 47(8-9):893-9. 2012.

Shiotani A, Manabe N, Kamada T, Fujimura Y, Sakakibara T, Haruma K: Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: a comprehensive review. Journal of gastroenterology and hepatology. 27 Suppl 3:8-12. 2012.

2011

Laboratory Hematology Branch

Matsuda K, Suzuki K, Ishihara S, Morinaga M, Okamoto M, Shiino Y, Horiuchi I, Tohyama K, Ichihara K: Assessment of the severity of organophosphate (fenitrothion) poisoning based on its serum concentration and clinical parameters. Clin Toxicol 49: 820-827, 2011.

Inaba T, Yuki Y, Yuasa S, Fujita N, Yoshitomi K, Kamisako T, Torii K, Okada T, Urasaki Y, Ueda T, Tohyama K: Clinical utility of the neutrophil distribution pattern obtained using the CELL-DYN SAPPHIRE hematology analyzer for the diagnosis of myelodysplastic syndrome. Int J Hematol 94: 169-77, 2011.

Tasaka T, Tohyama K,Ohyashiki K, Ozawa K: 5q- syndrome in Japan. Int J Hematol 93: 827-829, 2011.

Tsujioka T, Tohyama K : Application of laser scanning cytometry to clinical and laboratory hematology. in :Laser Scanning, Theory and Applications (edited by Wang CC), pp185-194, InTech, Rijeka, Croatia, 2011.

Yokoyama K, Kaji H, He J, Tanaka C, Hazama R, Kamigaki T, Ku Y, Tohyama K, Yumi Tohyama: Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes. J Biol Chem 286: 5375-5382, 2011.

Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam RL, Marra M, Karsan A: Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood 117: 595-607, 2011.

Tsujioka T, Kishimoto M, Kondo T, Matsuoka A, Tasaka T, Sugihara T, Wada H and ,Tohyama K: Impact of serum soluble interleukin-2 receptor levels on the diagnosis of malignant lymphoma. Kawsaki Medical Journal 37(1): 19-27, 2011.

Inoue T, Tashiro Y, Takeuchi M, Otani T, Tsuji-Takayama K, Okochi A, Mukae Y, Koreishi M, Yamasaki F, Kumon H, Nakamura S, Kibata M, Kondo E : Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins. Int J Oncol 38(5): 1299-306, 2011.

Endoscopy and Ultrasonography Branch

Manabe N, Haruma K, Kamada T, Kusunoki H, Inoue K, Murao T, Imamura H, Matsumoto H, Tarumi K, Shiotani A, Hata J: Changes of upper gastrointestinal symptoms and endoscopic findings in Japan over 25 years. Internal medicine. 50(13):1357-63. 2011.

Manabe N, Haruma K: Diagnosis and treatment of dyspeptic patients in Japan. Journal of gastroenterology and hepatology. 26 Suppl 3:27-31. 2011.

Manabe N, Haruma K, Imamura H, Kamada T, Kusunoki H, Inoue K, Shiotani A, Hata J: Does short-segment columnar-lined esophagus elongate during a mean follow-up period of 5.7 years? Digestive endoscopy. 23(2):166-72. 2011.

2010

Laboratory Hematology Branch

Matsuoka A, Tochigi A, Kishimoto M, Nakahara T, Kondo T,Tsujioka T, Tasaka T, Tohyama Y, Tohyama K: Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis. Leukemia 24: 748-755, 2010.

Akiyama N, Miyazawa K, Kanda Y, Tohyama K, Omine M, Mitani K, Ohyashiki K: Multicenter phase II trial of vitamin K2 monotherapy and vitamin K2 plus 1α-hydroxyvitamin D3 combination therapy for low-risk myelodysplastic syndromes. Leuk Res 34: 1151-1157, 2010.

Tamura H, Dan K, Yokose N, Iwakiri R, Ohta M, Sakamaki H, Tohyama K, Kondo A, Hyodo H, Nakamura K, Yamashita T, Elisseeva OA, Oka Y, Oji Y, Sugiyama H, Ogata K：Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheralblood in patients with myelodysplastic syndromes. Leuk Res 34: 986-990,2010.

Kubo Y, Kakazu N, Tasaka T, Oka D, Hirose T, Matsuhashi Y, Wada H, Tohyama K, Sugihara T: Acute lymphocytic leukemia(ALL) with t(8;14)(q11.2;q32) in an elderly patient. Leuk Res 34: e82-e84, 2010.

Endoscopy and Ultrasonography Branch

Manabe N, Rao AS, Wong BS, Camilleri M: Emerging pharmacologic therapies for irritable bowel syndrome. Current gastroenterology reports. 12(5):408-16. 2010.

Fujita M, Manabe N, Honda K, Tarumi K, Murao T, Katada S, Kimura Y, Matsumoto H, Kamada T, Shiotani A, Hata J, Haruma K: Long-term outcome after double-balloon endoscopy in patients with obscure gastrointestinal bleeding. Digestion. 82(3):173-8. 2010.

Manabe N, Haruma K, Hata J, Imamura H, Kamada T, Kusunoki H, Sanuki E, Tsumaru S, Futagami Y, Sadamoto Y, Tokutomi T, Kurose H: Clinical characteristics of Japanese dyspeptic patients: is the Rome III classification applicable? Scandinavian journal of gastroenterology. 45(5):567-72. 2010.

Manabe N, Wong BS, Camilleri M: New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders. Expert opinion on investigational drugs. 19(6):765-75. 2010.

Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, Zinsmeister AR, Haruma K: Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. American journal of physiology. Gastrointestinal and liver physiology. 298(6):G970-5. 2010.

Wong BS, Manabe N, Camilleri M: Role of prucalopride, a serotonin (5-HT(4)) receptor agonist, for the treatment of chronic constipation. Clinical and experimental gastroenterology. 3:49-56. 2010.

Manabe N, Hata J, Haruma K, Imamura H, Kamada T, Kusunoki H: Active gastrointestinal bleeding: evaluation with contrast-enhanced ultrasonography. Abdom Imaging. 35(6):637-42. 2010.

2009

Laboratory Hematology Branch

Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y,Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M,Ozawa K: Lenalidomide is active in Japanese patients with symptomatic anemia in low- or intermediate-1 risk myelodysplastic syndromes (MDS) with a deletion 5q abnormality. Int J Hematol 90: 353-360, 2009.

Kondo T, Tasaka T, Sano F, Matsuda K, Kubo Y, Matsuhashi Y, Nakanishi H, Sadahira Y, Wada H, Sugihara H, Tohyama K: Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) treated with imatinib mesylate (IM): a report with IM plasma concentration and bcr-abl transcripts. Leuk Res 33: e137-138, 2009.

Hazama R, Qu X, Yokoyama K, Tanaka C, Kinoshita E, He J, Takahashi S, Tohyama K, Yamamura H, Tohyama Y: ATP-induced osteoclast function; the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk. Genes to Cells 14: 871-884, 2009.

Mannouji K, Tasaka T, Akiyama T, Irei I, Sano F, Matsuhashi Y, Wada H, Tohyama K, Sugihara T, Sadahira Y: Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch. Pathol Internatl 59: 261-264, 2009.

Nishikawa Y, Sato H, Oka T, Yoshino T, Takahashi K: Immunohistochemical discrimination of plasmacytoid dendritic cells from myeloid dendritic cells in human pathological tissues. J Clin Exp Hematop 49: 23-31, 2009.

Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuchi K, Fujihara M, Kuraoka K, Nakai T, Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T: Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman’s disease. Mod Pathol 22: 589-99, 2009.

Endoscopy and Ultrasonography Branch

Manabe N, Tanaka T, Hata J, Kusunoki H, Haruma K: Pathophysiology underlying irritable bowel syndrome–from the viewpoint of dysfunction of autonomic nervous system activity. Journal of smooth muscle research. 45(1):15-23. 2009.

Sato M, Manabe N, Hata J, Ishii M, Kamada T, Kusunoki H, Shiotani A, Haruma K: Effect of irsogladine maleate on NSAID-induced reduction of gastric mucosal blood flow in anesthetized dogs. Digestion. 79(2):73-8. 2009.

2008

Laboratory Hematology Branch

Tasaka T, Tohyama K, Kishimoto M, Ohyashiki K, Mitani K, Hotta T, Kanamaru A, Okamoto S, Karasawa M, Kimura A, Tomonaga M, Uchiyama T, Ozawa K: Myelodysplastic syndrome (MDS) with chromosome 5 abnormalities : a nation-wide survey in Japan. Leukemia 22: 1874-1881, 2008.

Kondo T, Okuno N, Naruse H, Kishimoto M, Tasaka T, Tsujioka T, Matsuoka A, Sugihara T, Tohyama Y, Tohyama K: Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm. Leuk Lymphoma 49: 1784-1791, 2008.

Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A: High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 112: 3412-3424, 2008.

Higa T, Tasaka T, Kubo Y, Nakagiri I, Sano F, Matsuhashi Y, Fukai Y, Wada H, Tohyama K, Sugihara T: Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient. Scand J Infect Dis, 40: 990-992, 2008.

Tsujioka T, Tochigi A, Kishimoto M, Kondo T, Tasaka T, Wada H, Sugihara T, Tohyama K: DNA ploidy and cell cycle analysis in the bone marrow cells of the patients with megaloblastic anemia using a laser scanning cytometry. Cytometry B (Clin Cytometry) 74: 104-109, 2008.

Wakimoto T, Tomisaka R, Nishikawa Y, Sato H, Yoshino T, Takahashi K: Identification and characterization of human thymic cortical dendritic macrophages that may act as professional scavengers of apoptotic thymocytes. Immunobiology 213: 837-47, 2008.

Endoscopy and Ultrasonography Branch

Ishii M, Manabe N, Kusunoki H, Kamada T, Sato M, Imamura H, Shiotani A, Hata J, Haruma K: Real-time evaluation of dyspeptic symptoms and gastric motility induced by duodenal acidification using noninvasive transnasal endoscopy. Journal of gastroenterology. 43(12):935-41. 2008.

Kamino D, Manabe N, Hata J, Haruma K, Tanaka S, Chayama K: Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia. Journal of clinical biochemistry and nutrition. 42(2):144-9. 2008.

Manabe N, Haruma K, Hata J, Kamada T, Kusunoki H: Differences inrecognition of heartburn symptoms between Japanese patients with gastroesophageal reflux, physicians, nurses, and healthy lay subjects. Scandinavian journal of gastroenterology. 43(4):398-402. 2008.

2007

Laboratory Hematology Branch

Noda C, He J, Takano T, Tanaka C, Kondo T, Tohyama K, Yamamura H, Tohyama Y: Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells. Biochem Biophys Res Comm 362: 951-957, 2007.

Ishikawa T, Tohyama K, Nakao S, et al: A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55-CD59- blood cells predicts platelet response. Int J Hematol 86: 150-157, 2007.

Yang J, Ikezoe T, Nishioka C, Tasaka T, et al：AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 110: 2034-40, 2007.

Nishioka C, Ikezoe T, Takeshita A, Yang J, Tasaka T, et al：ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244. Leukemia 21: 1308-10, 2007.

Matsuhashi Y, Tasaka T, Kakazu N, et al：Establishment and characterization of the new splenic marginal zone lymphoma-derived cell line UCH1 carrying a complex rearrangement involving t(8;14) and chromosome 3. Leuk Lymphoma 48: 767-73, 2007.

Endoscopy and Ultrasonography Branch

Fukumoto A, Manabe N, Tanaka S, Yamaguchi T, Matsumoto Y, Chayama K: Usefulness of EUS with double-balloon enteroscopy for diagnosis of small-bowel diseases. Gastrointestinal endoscopy. 65(3):412-20. 2007.

2006

Laboratory Hematology Branch

Shi Y, Tohyama Y, Kadono T, He J, Shahjahan Miah SM, Hazama R, Tanaka C, Tohyama K, Yamamura H: Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis. Blood 107: 4554-62, 2006.

Tamechika Y, Iwatani Y, Tohyama K, Ichihara K: Insufficient filling of vacuum tubes as a cause of microhemolysis and elevated serum lactate dehydrogenase levels. Use of a data-mining technique in evaluation of questionable laboratory test results. Clin Chem Lab Med 44: 657-61, 2006.

Ikezoe T, Nishioka C, Tasaka T, et al: The antitumor effects of sunitinib(formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.　Mol Cancer Ther 10: 2522-30, 2006.

Tsujioka T, Miura Y, Otsuki T, Nishimura Y, Hyodoh F, Wada H, Sugihara T: The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 91: 613-619, 2006.

Miura Y, Tsujioka T, Nishimura Y, Sakaguchi H, Maeda M, Hayashi H, Dong M, Hyodoh F, Yata K, Wada H, Sugihara T, Otsuki T.: TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death. Anticancer Res 26: 4115-4124, 2006.

Kurihara R, Tohyama Y, Matsusaka S, Naruse H, Kinoshita E, Tsujioka T, Katsumata Y, Yamamura H: Effects of peripheral cannabimoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. J Biol Chem 281: 12908-12918, 2006.

Endoscopy and Ultrasonography Branch

Kunihiro K, Manabe N, Hata J, Kamino D, Nakao M, Mitsuoka Y, Tanaka S, Chayama K: Gastrointestinal stromal tumor in jejunum: diagnosis using contrast-enhanced ultrasonography and double-balloon enteroscopy. Digestive diseases and sciences. 51(7):1236-40. 2006.

Manabe N, Tanaka S, Fukumoto A, Nakao M, Kamino D, Chayama K: Double-balloon enteroscopy in patients with GI bleeding of obscure origin. Gastrointestinal endoscopy. 64(1):135-40. 2006.

2005

Laboratory Hematology Branch

Tohyama K, Shiga S, Itose Y, Uchihashi K, et al: Improved Detection of Minimal Acute Myeloid Leukemia Cells by the Use of the Combined Parameters of XE-2100 Hematology Analyzer. Cytometry B (Clin Cytometry) 66: 18-24, 2005.

He J, Tohyama Y, Yamamoto K, Kobayashi M, Shi Y, Takano T, Noda C, Tohyama K, Yamamura H: Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function. Genes to Cells　10: 23-35, 2005.

Matsusaka S, Tohyama Y, He J, Shi Y, Hazama R, Kadono T, Kurihara R, Tohyama K, Yamamura H: Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells. Biochem Biophys Res Comm 328: 1163-1169, 2005.

Endoscopy and Ultrasonography Branch

Yamaguchi T, Manabe N, Tanaka S, Fukumoto A, Shimamoto M, Nakao M, Kamino D, Chayama K: Multiple carcinoid tumors of the ileum preoperatively diagnosed by enteroscopy with the double-balloon technique. Gastrointestinal endoscopy. 62(2):315-8. 2005.

2004

Laboratory Hematology Branch

Tasaka T, Matsuhashi Y, Uehara E, Tamura T, Kakazu N, et al： Secondary acute monocytic leukemia with a translocation t(8;16)(p11;p13): case report and review of the literature. Leuk Lymphoma 45: 621-625, 2004.

Matsuhashi Y, Tasaka T, Uehara E, Fujimoto M, Fujita M, et al： Diffuse large B-cell lymphoma presenting with hypercalcemia and multiple osteolysis. Leuk Lymphoma 45: 397-400, 2004.

2003

Laboratory Hematology Branch

Tohyama K, Shiga S, Fujimoto H, Hamaguchi Y, Ichiyama S: Automated analysis of differentiation-induced leukemic cells during all-trans retinoic acid therapy of acute promyelocytic leukemia. Archiv Pathol Lab Med 127: e4-e10, 2003.

Shimamoto T, Tohyama K, Okamoto T, Uchiyama T, et al: Cyclosporin A therapy for patients with myelodysplastic syndrome: multicenter pilot studies in Japan. Leukemia Res 27: 783-788, 2003.

Nishihara T, Miura Y, Tohyama Y, Mizutani C, Hishita T, Ichiyama S, Uchiyama T, Tohyama K: Effects of Tyrosine Kinase Inhibitor, Imatinib Messylate on a Bcr-Abl-Positive Cell Line: Suppression of the Autonomous Cell Growth but No Effect on the Decreased Adhesive Property and Morphological Changes. Int J Hematol 78: 233-240, 2003.

Matsuhashi Y, Tasaka T, Uehara E, et al: Increased expression of c-maf in pure red cell aplasia secondary to plasma cell dyscrasia. Leuk Lymphoma 44: 523-524, 2003.

Tsujioka T,Wada H, Yamamori S, Otsuki T, Suemori S, Kondo T, Nakanishi H, Suetsugu Y, Mikami M, Sugihara T.: MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia. Int J Hematol 78(5): 439-442, 2003.

2002

Laboratory Hematology Branch

Ogata K, Nakamura K, Yokose N, Tamura H, Tachibana M, Taniguchi O, Iwakiri R, Hayashi T, Sakamaki H, Murai Y, Tohyama K, Tomoyasu S, Nonaka Y, Mori M, Dan K, Yoshida Y: Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndrome. Blood 100: 3887-3896, 2002.

Mizutani C, Tohyama Y, Miura Y, Hishita T, Nishihara T, Yamamura H, Ichiyama S, Uchiyama T, Tohyama K: Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation. Biochem Biophys Res Comm 297: 664-671, 2002.

Itoh M, Yago K, Shimada H, Tohyama K: Reversible acceleration of disease progression following cyclosporin A treatment in a patient with myelodysplastic syndrome. Int J Hematol 75: 302-304, 2002.

Shiga S, Fujimoto H, Mori Y, Sakata T, Hamaguchi Y, Wang F-S, Inomata Y, Tohyama K, Ichiyama S: Immature granulocyte count after liver transplantation. Clin Chem Lab Med 40: 775-780, 2002.

Endoscopy and Ultrasonography Branch

Manabe N, Yoshihara M, Sasaki A, Tanaka S, Haruma K, Chayama K: Clinical characteristics and natural history of patients with low-grade reflux esophagitis. Journal of gastroenterology and hepatology. 17(9):949-54. 2002.

Fujita M, Koga H, Iida M, Hirakawa K, Hoshika K, Haruma K, Okino T: The diagnostic yield of colonoscopy and the therapeutic value of intraduodenal amidotrizoic acid injection in intestinal Diphyllobothrium latum infection: report of a case. The American journal of gastroenterology. 97(9):2468-70. 2002.