{"id":948,"date":"2024-02-12T00:00:00","date_gmt":"2024-02-11T15:00:00","guid":{"rendered":"https:\/\/m.kawasaki-m.ac.jp\/mgm-lyso\/?p=948"},"modified":"2025-07-14T16:50:07","modified_gmt":"2025-07-14T07:50:07","slug":"%e6%8e%b2%e8%bc%89%e6%83%85%e5%a0%b1%ef%bc%88%e8%ab%96%e6%96%87%ef%bc%89-4","status":"publish","type":"post","link":"https:\/\/m.kawasaki-m.ac.jp\/mgm-lyso\/?p=948","title":{"rendered":"\u63b2\u8f09\u60c5\u5831\uff08\u8ad6\u6587\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u306e\u9178\u6027\u30ad\u30e3\u30d1\u30b7\u30c6\u30a3\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/strong><br><br>\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u9178\u6027\u30ea\u30d1\u30fc\u30bc\u3092\u6b20\u640d\u3055\u305b\u305f\u7d30\u80de\uff08<em>LIPA<\/em>\u907a\u4f1d\u5b50\u6b20\u640d\u7d30\u80de\u3001\u9178\u6027\u30ea\u30d1\u30fc\u30bc\u6b20\u640d\u75c7\u306e\u30e2\u30c7\u30eb\uff09\u306b\u304a\u3044\u3066\u306f\u3001\u7d30\u80de\u5185\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4ee3\u8b1d\u304c\u969c\u5bb3\u3055\u308c\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u84c4\u7a4d\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3053\u306e\u7d30\u80de\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u304c\u80a5\u5927\u5316\u3057\u3001\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u306e\u9178\u6027\u3092\u4fdd\u6301\u3059\u308b\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u304a\u3051\u308b\u5206\u89e3\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u306e\u9178\u6027\u7dad\u6301\u80fd\u529b\u4f4e\u4e0b\u306f\u3001\u907a\u4f1d\u7684\u306b\u6b20\u640d\u304c\u306a\u3044\uff08\u6b63\u5e38\uff09\u7d30\u80de\u306b\u304a\u3044\u3066\u57f9\u990a\u6db2\u4e2d\u306b\u901a\u5e38\u306e2\u500d\u7a0b\u5ea6\u306e\u6fc3\u5ea6\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3082\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<br><br>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u75c5\u3067\u3042\u308b\u9178\u6027\u30ea\u30d1\u30fc\u30bc\u6b20\u640d\u75c7\uff08Wolman\u75c5\u30fb\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30a8\u30b9\u30c6\u30eb\u84c4\u7a4d\u75c7\uff08CESD\uff09\uff09\u306e\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u306e\u89e3\u660e\u3068\u306a\u308b\u306e\u307f\u306a\u3089\u305a\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u3088\u3046\u306a\u751f\u6d3b\u7fd2\u6163\u75c5\u304c\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u6a5f\u80fd\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u307e\u3059\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u4f4e\u4e0b\u306f\u30a8\u30a4\u30b8\u30f3\u30b0\u306a\u3069\u5e45\u5e83\u304f\u306e\u751f\u547d\u73fe\u8c61\u306b\u95a2\u9023\u3059\u308b\u610f\u5473\u3067\u3082\u91cd\u8981\u3067\u3059\u3002<br><br><strong>Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy.<\/strong><br>Moriwaki T, Terawaki S, *Otomo T.<br><strong><em>J Biol Chem<\/em><\/strong>, 2024 Feb 12:105743. doi: 10.1016\/j.jbc.2024.105743<br><span style=\"text-decoration: underline;\"><span class=\"has-inline-color has-vivid-purple-color\"><a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38354786\/\" target=\"_blank\">PMID: 38354786<\/a><\/span><\/span><span class=\"has-inline-color has-vivid-purple-color\"><br><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u306e\u9178\u6027\u30ad\u30e3\u30d1\u30b7\u30c6\u30a3\u3092\u4f4e\u4e0b\u3055\u305b\u308b 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