{"id":1020,"date":"2025-07-18T12:00:00","date_gmt":"2025-07-18T03:00:00","guid":{"rendered":"https:\/\/m.kawasaki-m.ac.jp\/mgm-lyso\/?p=1020"},"modified":"2026-02-02T13:43:43","modified_gmt":"2026-02-02T04:43:43","slug":"%e6%8e%b2%e8%bc%89%e6%83%85%e5%a0%b1%ef%bc%88%e8%ab%96%e6%96%87%ef%bc%89-6","status":"publish","type":"post","link":"https:\/\/m.kawasaki-m.ac.jp\/mgm-lyso\/?p=1020","title":{"rendered":"\u63b2\u8f09\u60c5\u5831\uff08\u8ad6\u6587\uff09"},"content":{"rendered":"\n

\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u306f\u7d30\u80de\u306e\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\uff08\u30e0\u30b3\u591a\u7cd6\uff09\u30ec\u30d9\u30eb\u3092\u6291\u5236\u3059\u308b \u301c \u30e0\u30b3\u591a\u7cd6\u75c7\u304a\u3088\u3073\u30e0\u30b3\u591a\u7cd6\u75c7\u95a2\u9023\u75be\u60a3\u306e\u6cbb\u7642\u85ac\u5019\u88dc<\/strong><\/p>\n\n\n\n

\u30e0\u30b3\u591a\u7cd6\u75c7\u3001\u30e0\u30b3\u30ea\u30d4\u30c9\u30fc\u30b7\u30b9\u3001\u30e0\u30b3\u591a\u7cd6\u75c7\u30d7\u30e9\u30b9\u75c7\u5019\u7fa4\u7b49\u3067\u306f\u3001\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\uff08GAG\uff09\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3068\u5168\u8eab\u75c7\u72b6\u3092\u304d\u305f\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306f\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u7d042,000\u7a2e\u985e\u306e\u65e2\u5b58\u85ac\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3001GAG\u3092\u6e1b\u3089\u3059\u52b9\u679c\u306e\u3042\u308b\u85ac\u5264\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u306f\u7c73\u56fd\u3067\u306f\u6297\u5bc4\u751f\u866b\u85ac\u3068\u3057\u3066\u627f\u8a8d\u30fb\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u65e5\u672c\u3067\u306f\u672a\u627f\u8a8d\u306e\u85ac\u5264\u3067\u3059\u3002

\u79c1\u305f\u3061\u306f\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\uff08CRISPR\/Cas9\uff09\u3092\u7528\u3044\u3066\u30e0\u30b3\u591a\u7cd6\u75c7I\u578b\u3001II\u578b\u3001VI\u578b\u3001VII\u578b\u3001\u30e0\u30b3\u30ea\u30d4\u30c9\u30fc\u30b7\u30b9II\u578b\u7b49\u306e\u75be\u60a3\u30e2\u30c7\u30eb\u7d30\u80de\u682a\u3092\u4f5c\u88fd\u3057\u3001\u307e\u305f\u7d30\u80de\u5b9f\u9a13\u7cfb\u306b\u304a\u3044\u3066\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u3001\u30c7\u30eb\u30de\u30bf\u30f3\u786b\u9178\u3001\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u786b\u9178\u7b49\u306e\u5e45\u5e83\u3044GAG\u306e\u30b3\u30a2\u86cb\u767d\u3092\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u3092\u7acb\u3061\u4e0a\u3052\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u306f\u3053\u308c\u3089\u306e\u75be\u60a3\u30e2\u30c7\u30eb\u7d30\u80de\u306b\u304a\u3044\u3066\u5e45\u5e83\u3044\u7a2e\u985e\u306eGAG\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\u3055\u3089\u306b\u3001\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u306f\u30e0\u30b3\u591a\u7cd6\u75c7\u30d7\u30e9\u30b9\u75c7\u5019\u7fa4\u306e\u60a3\u8005\u7d30\u80de\u304a\u3044\u3066\u3082GAG\u3092\u6e1b\u5c11\u3055\u305b\u3001\u7d30\u80de\u5185\u306e\u7570\u5e38\u306a\u30a8\u30f3\u30c9\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3057\u305f\u3002\u30e0\u30b3\u591a\u7cd6\u75c7\u30d7\u30e9\u30b9\u75c7\u5019\u7fa4\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u305f\u3068\u3053\u308d\u3001\u80ce\u751f\u65e9\u671f\u306b\u81f4\u6b7b\u3068\u306a\u308b\u3053\u3068\u304c\u5224\u308a\u307e\u3057\u305f\u304c\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u30de\u30a6\u30b9\u306e\u98f2\u6c34\u4e2d\u306b\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u3092\u6df7\u305c\u3066\u6295\u4e0e\u3059\u308b\u3068\u3001\u51fa\u7523\u76f4\u524d\u307e\u3067\u80ce\u5150\u304c\u6210\u9577\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002

\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u30c8\u30ea\u30af\u30e9\u30d9\u30f3\u30c0\u30be\u30fc\u30eb\u306fGAG\u306e\u4ee3\u8b1d\u7570\u5e38\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u30e0\u30b3\u591a\u7cd6\u75c7\u3084\u30e0\u30b3\u591a\u7cd6\u75c7\u95a2\u9023\u75be\u60a3\u306e\u6cbb\u7642\u85ac\u5019\u88dc\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u672c\u6210\u679c\u3092\u53d7\u3051\u3001\u79c1\u305f\u3061\u306f\u4eca\u5f8c\u6cbb\u7642\u85ac\u958b\u767a\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002


Triclabendazole suppresses cellular levels of glycosaminoglycan\u2014A potential therapeutic agent for mucopolysaccharidoses and related diseases.<\/strong>
Terawaki S, Vasilev F, Sofronova V, Tanaka M, Mori Y, Iwata R, Moriwaki T, Fujita T, Maksimova N, *Otomo T.
iScience<\/em><\/strong>, 2025, 28<\/em>(8): 113118
DOI:\u00a0https:\/\/doi.org\/10.1016\/j.isci.2025.113118<\/span><\/span><\/a>

<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n


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